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Assay Detail

CHEMBL684279

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for agonistic potency to inhibit contractile force in isolated guinea pig atria
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 1 — Organism
Curated By Intermediate

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties
Knutsen LJ, Lau J, Sheardown MJ, Thomsen C
Bioorg Med Chem Lett (1993) 3 : 2661 -2666
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.09 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL88815 1 6.72
CHEMBL413506 1 6.50
CHEMBL88963 1 6.50
CHEMBL68738 N6-CYCLOPENTYLADENOSINE 1 6.38
CHEMBL315056 1 6.36
CHEMBL327195 1 6.33
CHEMBL423315 1 6.24
CHEMBL88439 1 6.19
CHEMBL316112 1 5.89
CHEMBL91304 1 5.54
CHEMBL92311 1 5.35
CHEMBL312917 1 5.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL88815 IC50 = 190.0 nM 6.72
CHEMBL413506 IC50 = 320.0 nM 6.50
CHEMBL88963 IC50 = 320.0 nM 6.50
CHEMBL68738 N6-CYCLOPENTYLADENOSINE IC50 = 420.0 nM 6.38
CHEMBL315056 IC50 = 440.0 nM 6.36
CHEMBL327195 IC50 = 470.0 nM 6.33
CHEMBL423315 IC50 = 580.0 nM 6.24
CHEMBL88439 IC50 = 640.0 nM 6.19
CHEMBL316112 IC50 = 1290.0 nM 5.89
CHEMBL91304 IC50 = 2900.0 nM 5.54
CHEMBL92311 IC50 = 4500.0 nM 5.35
CHEMBL312917 IC50 = 8200.0 nM 5.09