Assay Detail
Functional
CHEMBL684280
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Tested for agonistic potency to inhibit stimulated cAMP accumulation in isolated guinea pig heart
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.89 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88815 | — | — | 1 | 10.52 |
| CHEMBL88439 | — | — | 1 | 9.52 |
| CHEMBL315056 | — | — | 1 | 9.40 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.22 |
| CHEMBL88963 | — | — | 1 | 9.15 |
| CHEMBL91304 | — | — | 1 | 8.96 |
| CHEMBL423315 | — | — | 1 | 8.68 |
| CHEMBL413506 | — | — | 1 | 8.60 |
| CHEMBL316112 | — | — | 1 | 8.42 |
| CHEMBL327195 | — | — | 1 | 8.34 |
| CHEMBL92311 | — | — | 1 | 8.32 |
| CHEMBL312917 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88815 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL88439 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL315056 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL88963 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL91304 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL423315 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL413506 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL316112 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL327195 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL92311 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL312917 | — | IC50 | = | 27.0 | nM | 7.57 |