Assay Detail
Functional
CHEMBL684398
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Tested for concentration required to inhibit H1 histamine -induced guinea pig ileum contraction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.95 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91397 | RUPATADINE | 4.0 | 1 | 8.41 |
| CHEMBL544552 | — | — | 1 | 7.43 |
| CHEMBL90893 | — | — | 1 | 7.03 |
| CHEMBL555304 | — | — | 1 | 6.72 |
| CHEMBL91729 | — | — | 1 | 6.57 |
| CHEMBL88343 | — | — | 1 | 6.55 |
| CHEMBL92108 | — | — | 1 | 6.46 |
| CHEMBL544551 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91397 | RUPATADINE | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL544552 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL90893 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL555304 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL91729 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL88343 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL92108 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL544551 | — | IC50 | = | 360.0 | nM | 6.44 |