Assay Detail
Functional
CHEMBL684399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for concentration required to inhibit histamine -induced ileum contraction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.81 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329547 | — | — | 1 | 7.19 |
| CHEMBL329451 | — | — | 1 | 6.89 |
| CHEMBL91261 | — | — | 1 | 6.68 |
| CHEMBL91455 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329547 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL329451 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL91261 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL91455 | — | IC50 | = | 350.0 | nM | 6.46 |