Assay Detail
Functional
CHEMBL684402
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Tested for potent reversible agonist activity on electrically stimulated guinea pig ileal longitudinal muscle preparation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.70 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473136 | — | — | 1 | 8.32 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.62 |
| CHEMBL78205 | — | — | 1 | 7.57 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473136 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL70 | MORPHINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL78205 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL19019 | NALTREXONE | IC50 | = | 50.0 | nM | 7.30 |