Assay Detail
Binding
CHEMBL684416
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Inhibition of [125I]glucagon binding towards Glucagon receptor
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.42 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429362 | — | — | 1 | 8.82 |
| CHEMBL413666 | — | — | 1 | 8.64 |
| CHEMBL2115191 | — | — | 1 | 8.39 |
| CHEMBL3037804 | — | — | 1 | 8.00 |
| CHEMBL2114176 | — | — | 1 | 7.46 |
| CHEMBL2369127 | — | — | 1 | 7.13 |
| CHEMBL328942 | — | — | 3 | 6.92 |
| CHEMBL2114177 | — | — | 1 | 6.40 |
| CHEMBL2115192 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429362 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL413666 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2115191 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3037804 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2114176 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL2369127 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL328942 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL328942 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL328942 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2114177 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL2115192 | — | IC50 | = | 510.0 | nM | 6.29 |