Compound Detail

CHEMBL429362

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc1c[nH]cn1)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)[C@@H](C)O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL429362
Phase	Preclinical
Structure Type	BOTH
InChI Key	MASNOZXLGMXCHN-FOVRWHHWSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

3482.8

MW (Da)

Drug Information

Molecule Type	Protein
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C153H225N43O49S
MW	3482.80

Activity Summary

EC50 1 meas. best 8.1

IC50 1 meas. best 8.82

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Glucagon receptor CHEMBL4720	IC50	8.82	8.82	1.5	1
Adenylate cyclase type 5 CHEMBL3189	EC50	8.1	8.1	8.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Glucagon receptor	IC50	=	1.5	nM	8.82	Inhibition of [125I]glucagon binding towards Glucagon receptor	8691441
Adenylate cyclase type 5	EC50	=	8.0	nM	8.1	Ability of the Compound to activate Adenylate cyclase activity was measured by t...	8691441

Literature References

PubMed	DOI	Target Context	# Activities
8691441	10.1021/jm960130b	Glucagon receptor	2
8691441	10.1021/jm960130b	Adenylate cyclase type 5	2

Data from ChEMBL 36 via Core Engine