Assay Detail
Functional
CHEMBL684494
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Agonist activity by measuring the ability to stimulate the contraction of the isolated guinea pig ileum.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of CCK26-33-related analogues modified in position 31.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.04 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384035 | — | — | 1 | 9.40 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.15 |
| CHEMBL264597 | — | — | 1 | 7.96 |
| CHEMBL409220 | — | — | 1 | 6.96 |
| CHEMBL410230 | — | — | 1 | 6.72 |
| CHEMBL409961 | — | — | 1 | - |
| CHEMBL409963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384035 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1121 | SINCALIDE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL264597 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL409220 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL410230 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL409961 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL409963 | — | EC50 | > | 1000.0 | nM | - |