Assay Detail
Functional
CHEMBL684495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity by measuring the effect on amylase secretion from guinea pig acini.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of CCK26-33-related analogues modified in position 31.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.68 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.89 |
| CHEMBL384035 | — | — | 1 | 9.80 |
| CHEMBL264597 | — | — | 1 | 8.47 |
| CHEMBL410230 | — | — | 1 | 7.66 |
| CHEMBL409220 | — | — | 1 | 7.60 |
| CHEMBL409961 | — | — | 1 | - |
| CHEMBL409963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL384035 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL264597 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL410230 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL409220 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL409961 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL409963 | — | EC50 | > | 10000.0 | nM | - |