Assay Detail
Functional
CHEMBL684532
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Compound was evaluated for its activity in vitro with use of isolated guinea pig tracheal spiral strips in the presence of L-serine borate (45 mM)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemically stable homocinnamyl analogues of the leukotrienes: synthesis and preliminary biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.74 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82239 | — | — | 1 | 9.28 |
| CHEMBL85191 | — | — | 1 | 7.13 |
| CHEMBL315406 | — | — | 1 | 6.59 |
| CHEMBL52757 | — | — | 1 | 6.35 |
| CHEMBL312591 | — | — | 1 | 6.35 |
| CHEMBL83672 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82239 | — | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL85191 | — | EC50 | = | 74.5 | nM | 7.13 |
| CHEMBL315406 | — | EC50 | = | 256.0 | nM | 6.59 |
| CHEMBL52757 | — | EC50 | = | 447.0 | nM | 6.35 |
| CHEMBL312591 | — | EC50 | = | 451.0 | nM | 6.35 |
| CHEMBL83672 | — | EC50 | = | 18400.0 | nM | 4.74 |