Assay Detail
Functional
CHEMBL684535
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In vitro agonistic activity on isolated guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.97 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 6.77 |
| CHEMBL38756 | — | — | 1 | 5.22 |
| CHEMBL289894 | — | — | 1 | 4.92 |
| CHEMBL287834 | — | — | 1 | 4.92 |
| CHEMBL291280 | — | — | 1 | 4.77 |
| CHEMBL39922 | — | — | 1 | 4.66 |
| CHEMBL39843 | — | — | 1 | 4.52 |
| CHEMBL290715 | — | — | 1 | 4.00 |
| CHEMBL38423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL38756 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL289894 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL287834 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL291280 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL39922 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL39843 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL290715 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL38423 | — | EC50 | = | 150000.0 | nM | - |