Assay Detail
Functional
CHEMBL684544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro increase in contractile force of the guine pig atrium.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
17 alpha-O-(aminoalkyl)oxime derivatives of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane as inhibitors of Na(+),K(+)-ATPase at the digitalis receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.68 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 7.24 |
| CHEMBL126930 | — | — | 1 | 5.82 |
| CHEMBL126063 | — | — | 1 | 5.70 |
| CHEMBL124276 | — | — | 1 | 5.52 |
| CHEMBL2069053 | — | — | 1 | 5.46 |
| CHEMBL124697 | — | — | 1 | 5.25 |
| CHEMBL2069098 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1453 | DIGITOXIGENIN | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL126930 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL126063 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL124276 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2069053 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL124697 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2069098 | — | EC50 | = | 18000.0 | nM | 4.75 |