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Assay Detail

CHEMBL684549

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration that elicits 50% of its own maximum contractile response, in guinea pig ileum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 1 — Organism
Curated By Intermediate

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Nilsson BM, Ringdahl B, Hacksell U.
J Med Chem (1988) 31 : 577 -582
PubMed 3346873 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.73 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL11081 1 7.16
CHEMBL14 CARBACHOL 4.0 1 6.96
CHEMBL310852 1 6.72
CHEMBL346737 1 6.00
CHEMBL348172 1 5.92
CHEMBL346237 1 5.70
CHEMBL154642 1 5.60
CHEMBL352248 1 5.26
CHEMBL152593 1 4.77
CHEMBL157438 1 4.57
CHEMBL348075 1 4.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL11081 EC50 = 69.0 nM 7.16
CHEMBL14 CARBACHOL EC50 = 110.0 nM 6.96
CHEMBL310852 EC50 = 190.0 nM 6.72
CHEMBL346737 EC50 = 1000.0 nM 6.00
CHEMBL348172 EC50 = 1200.0 nM 5.92
CHEMBL346237 EC50 = 2000.0 nM 5.70
CHEMBL154642 EC50 = 2500.0 nM 5.60
CHEMBL352248 EC50 = 5500.0 nM 5.26
CHEMBL152593 EC50 = 16900.0 nM 4.77
CHEMBL157438 EC50 = 27100.0 nM 4.57
CHEMBL348075 EC50 = 38800.0 nM 4.41