Assay Detail
Functional
CHEMBL684555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for increasing potency force in guinea pig isolated left atria
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-Aralkyl substitution of 2-amino-5,6- and -6,7-dihydroxy-1,2,3,4-tetrahydronaphthalenes. 1. Cardiac and pressor/depressor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.01 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 8.49 |
| CHEMBL926 | DOBUTAMINE | 4.0 | 1 | 6.82 |
| CHEMBL170673 | — | — | 1 | 6.60 |
| CHEMBL109422 | — | — | 1 | 6.55 |
| CHEMBL353237 | — | — | 1 | 6.14 |
| CHEMBL168517 | — | — | 1 | 5.82 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.77 |
| CHEMBL26736 | — | — | 1 | 5.60 |
| CHEMBL163912 | — | — | 1 | 5.36 |
| CHEMBL354047 | — | — | 1 | 4.68 |
| CHEMBL355267 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL926 | DOBUTAMINE | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL170673 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL109422 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL353237 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL168517 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL59 | DOPAMINE | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL26736 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL163912 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL354047 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL355267 | — | EC50 | = | 49000.0 | nM | 4.31 |