Assay Detail
Functional
CHEMBL684557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for increasing potency rate in guinea pig isolated right atria
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-Aralkyl substitution of 2-amino-5,6- and -6,7-dihydroxy-1,2,3,4-tetrahydronaphthalenes. 1. Cardiac and pressor/depressor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.94 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 8.21 |
| CHEMBL170673 | — | — | 1 | 6.80 |
| CHEMBL926 | DOBUTAMINE | 4.0 | 1 | 6.33 |
| CHEMBL166287 | — | — | 1 | 5.92 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.82 |
| CHEMBL354047 | — | — | 1 | 5.77 |
| CHEMBL353237 | — | — | 1 | 5.75 |
| CHEMBL26736 | — | — | 1 | 4.48 |
| CHEMBL163912 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL170673 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL926 | DOBUTAMINE | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL166287 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL59 | DOPAMINE | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL354047 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL353237 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL26736 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL163912 | — | EC50 | = | 38000.0 | nM | 4.42 |