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Assay Detail

CHEMBL684565

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of electrically stimulated contractions of the isolated guinea pig badder.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.
Berardi F, Ferorelli S, Abate C, Colabufo NA, Contino M, Perrone R, Tortorella V.
J Med Chem (2004) 47 : 2308 -2317
PubMed 15084129 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 5.28 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73854 1 5.82
CHEMBL419822 1 5.76
CHEMBL75480 1 5.74
CHEMBL53325 1 5.58
CHEMBL75372 1 5.53
CHEMBL306365 1 5.31
CHEMBL282433 DITOLYLGUANIDINE 1 5.16
CHEMBL309064 1 5.16
CHEMBL77220 1 5.00
CHEMBL75878 1 4.94
CHEMBL74858 1 4.79
CHEMBL74811 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73854 EC50 = 1500.0 nM 5.82
CHEMBL419822 EC50 = 1750.0 nM 5.76
CHEMBL75480 EC50 = 1820.0 nM 5.74
CHEMBL53325 EC50 = 2620.0 nM 5.58
CHEMBL75372 EC50 = 2950.0 nM 5.53
CHEMBL306365 EC50 = 4900.0 nM 5.31
CHEMBL282433 DITOLYLGUANIDINE EC50 = 6900.0 nM 5.16
CHEMBL309064 EC50 = 6970.0 nM 5.16
CHEMBL77220 EC50 = 9940.0 nM 5.00
CHEMBL75878 EC50 = 11500.0 nM 4.94
CHEMBL74858 EC50 = 16100.0 nM 4.79
CHEMBL74811 EC50 = 25300.0 nM 4.60