Assay Detail
Functional
CHEMBL684571
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Inhibition of spontaneous tone in guinea pig tracheal spirals
24
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogues in guinea pig trachealis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.80 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86733 | — | — | 1 | 7.02 |
| CHEMBL45314 | — | — | 1 | 6.85 |
| CHEMBL86859 | — | — | 1 | 6.60 |
| CHEMBL83019 | — | — | 1 | 6.36 |
| CHEMBL87254 | — | — | 1 | 6.02 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 5.96 |
| CHEMBL86136 | — | — | 1 | 5.94 |
| CHEMBL86728 | — | — | 1 | 5.92 |
| CHEMBL87960 | — | — | 1 | 5.87 |
| CHEMBL419493 | — | — | 1 | 5.87 |
| CHEMBL86732 | — | — | 1 | 5.67 |
| CHEMBL86649 | — | — | 2 | 5.47 |
| CHEMBL86729 | — | — | 1 | 5.36 |
| CHEMBL85703 | — | — | 2 | 5.25 |
| CHEMBL86544 | — | — | 1 | 5.19 |
| CHEMBL314006 | — | — | 2 | 4.96 |
| CHEMBL89129 | — | — | 1 | 4.93 |
| CHEMBL314027 | — | — | 1 | - |
| CHEMBL87322 | — | — | 1 | - |
| CHEMBL85173 | — | — | 1 | - |
| CHEMBL86628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86733 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL45314 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL86859 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL83019 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL87254 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL49035 | CROMAKALIM | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL86136 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL86728 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL419493 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL87960 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL86732 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL86649 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL86729 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL85703 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL85703 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL86544 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL314006 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL89129 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL85173 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL86628 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL86649 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL314006 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL87322 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL314027 | — | IC50 | > | 20000.0 | nM | - |