Assay Detail
Functional
CHEMBL684573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tonic (slow) component of K+ depolarization response in guinea pig ileal longitudinal smooth muscle
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.59 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441428 | — | — | 1 | 9.66 |
| CHEMBL317044 | — | — | 1 | 9.57 |
| CHEMBL102907 | — | — | 1 | 9.23 |
| CHEMBL103806 | — | — | 1 | 8.68 |
| CHEMBL105444 | — | — | 1 | 8.48 |
| CHEMBL319033 | — | — | 1 | 8.17 |
| CHEMBL102498 | — | — | 1 | 8.15 |
| CHEMBL321999 | — | — | 1 | 7.82 |
| CHEMBL318521 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441428 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL317044 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL102907 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL103806 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL105444 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL319033 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL102498 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL321999 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL318521 | — | IC50 | = | 27.0 | nM | 7.57 |