Assay Detail
Functional
CHEMBL684574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of twitches in guinea pig ileum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity studies of dermorphin. Synthesis and some pharmacological data of dermorphin and its 1-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.67 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | — | 1 | 10.28 |
| CHEMBL595972 | — | — | 1 | 8.60 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | IC50 | = | 0.052 | nM | 10.28 |
| CHEMBL595972 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL70 | MORPHINE | IC50 | = | 75.0 | nM | 7.12 |