Assay Detail
Functional
CHEMBL685012
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Inhibitory activity against Leukotriene C4 induced contractions
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.47 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52896 | — | — | 3 | 6.04 |
| CHEMBL54453 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52896 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL52896 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL54453 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL52896 | — | IC50 | = | 30000.0 | nM | 4.52 |