Assay Detail
Binding
CHEMBL685137
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Steroid binding against the rat thymus glucocorticoid receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Anti-inflammatory 17beta-thioalkyl-16alpha,17alpha-ketal and -acetal androstanes: a new class of airway selective steroids for the treatment of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.47 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357651 | — | — | 1 | 8.80 |
| CHEMBL343438 | — | — | 1 | 8.77 |
| CHEMBL2112857 | — | — | 1 | 8.74 |
| CHEMBL344763 | — | — | 1 | 8.68 |
| CHEMBL144551 | — | — | 1 | 8.66 |
| CHEMBL344563 | — | — | 1 | 8.66 |
| CHEMBL144319 | — | — | 1 | 8.66 |
| CHEMBL1908322 | TIPREDANE | 2.0 | 1 | 8.64 |
| CHEMBL342304 | — | — | 1 | 8.62 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 8.54 |
| CHEMBL436070 | — | — | 1 | 8.49 |
| CHEMBL143729 | — | — | 1 | 8.48 |
| CHEMBL344512 | — | — | 1 | 8.48 |
| CHEMBL2112850 | — | — | 1 | 8.37 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | 4.0 | 1 | 8.30 |
| CHEMBL2112858 | — | — | 1 | 8.28 |
| CHEMBL146781 | — | — | 1 | 8.26 |
| CHEMBL144841 | — | — | 1 | 7.92 |
| CHEMBL435878 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357651 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL343438 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2112857 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL344763 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL144551 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL344563 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL144319 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1908322 | TIPREDANE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL342304 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL436070 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL143729 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL344512 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2112850 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1473 | FLUTICASONE PROPIONATE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2112858 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL146781 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL144841 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL435878 | — | IC50 | = | 22.0 | nM | 7.66 |