Assay Detail
Functional
CHEMBL685161
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Inhibition of LTC4-induced contractions from guinea pig peripheral lung strips
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18918 | — | — | 1 | 8.70 |
| CHEMBL18518 | RG-12525 | — | 1 | 8.57 |
| CHEMBL18699 | — | — | 1 | 8.38 |
| CHEMBL279849 | — | — | 1 | 8.20 |
| CHEMBL18866 | — | — | 1 | 8.10 |
| CHEMBL18956 | — | — | 1 | 8.05 |
| CHEMBL18589 | — | — | 1 | 8.05 |
| CHEMBL18204 | — | — | 1 | 8.02 |
| CHEMBL418002 | — | — | 1 | 7.92 |
| CHEMBL18816 | — | — | 1 | 7.92 |
| CHEMBL18671 | — | — | 1 | 7.92 |
| CHEMBL18396 | — | — | 1 | 7.89 |
| CHEMBL276136 | — | — | 1 | 7.85 |
| CHEMBL18919 | — | — | 1 | 7.80 |
| CHEMBL18413 | — | — | 1 | 7.72 |
| CHEMBL18405 | — | — | 1 | 7.70 |
| CHEMBL279770 | — | — | 1 | 7.70 |
| CHEMBL18381 | — | — | 1 | 7.70 |
| CHEMBL18833 | — | — | 1 | 7.70 |
| CHEMBL417271 | — | — | 1 | 7.62 |
| CHEMBL19072 | — | — | 1 | 7.57 |
| CHEMBL18597 | — | — | 1 | 7.47 |
| CHEMBL277831 | — | — | 1 | 7.44 |
| CHEMBL18339 | — | — | 1 | 7.36 |
| CHEMBL19102 | — | — | 1 | 7.12 |
| CHEMBL18979 | — | — | 1 | 7.00 |
| CHEMBL267475 | FPL-55712 | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18918 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL18518 | RG-12525 | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL18699 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL279849 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL18866 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL18956 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL18589 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL18204 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL418002 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL18816 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL18671 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL18396 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL276136 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL18919 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL18413 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL18405 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL279770 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL18381 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL18833 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL417271 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL19072 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL18597 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL277831 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL18339 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL19102 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL18979 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL267475 | FPL-55712 | IC50 | = | 940.0 | nM | 6.03 |