Assay Detail
Functional
CHEMBL685183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required in vitro for tracheal muscle (from male Hartley guinea pigs) relaxation
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 5.37 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157655 | — | — | 1 | 7.30 |
| CHEMBL28559 | — | — | 1 | 7.22 |
| CHEMBL28075 | — | — | 1 | 7.16 |
| CHEMBL29518 | — | — | 1 | 6.70 |
| CHEMBL27967 | — | — | 1 | 6.29 |
| CHEMBL29272 | — | — | 1 | 6.16 |
| CHEMBL28194 | — | — | 1 | 5.89 |
| CHEMBL29461 | — | — | 1 | 5.80 |
| CHEMBL286976 | — | — | 1 | 5.80 |
| CHEMBL32241 | — | — | 1 | 5.77 |
| CHEMBL27969 | — | — | 1 | 5.72 |
| CHEMBL32184 | — | — | 1 | 5.57 |
| CHEMBL445847 | — | — | 1 | 5.54 |
| CHEMBL282394 | — | — | 1 | 5.46 |
| CHEMBL288786 | — | — | 1 | 5.38 |
| CHEMBL283024 | — | — | 1 | 5.34 |
| CHEMBL282310 | — | — | 1 | 5.30 |
| CHEMBL283454 | — | — | 1 | 5.29 |
| CHEMBL283412 | — | — | 1 | 5.23 |
| CHEMBL279898 | ENPROFYLLINE | 2.0 | 1 | 5.14 |
| CHEMBL287180 | — | — | 1 | 4.95 |
| CHEMBL31859 | — | — | 1 | 4.91 |
| CHEMBL31838 | — | — | 1 | 4.88 |
| CHEMBL28603 | — | — | 1 | 4.83 |
| CHEMBL28980 | — | — | 1 | 4.78 |
| CHEMBL282160 | — | — | 1 | 4.69 |
| CHEMBL28419 | — | — | 1 | 4.67 |
| CHEMBL28300 | — | — | 1 | 4.65 |
| CHEMBL28683 | — | — | 1 | 4.56 |
| CHEMBL628 | PENTOXIFYLLINE | 4.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157655 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL28559 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL28075 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL29518 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL27967 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL29272 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL28194 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL29461 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL286976 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL32241 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL27969 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL32184 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL445847 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL282394 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL288786 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL283024 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL282310 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL283454 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL283412 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL279898 | ENPROFYLLINE | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL287180 | — | EC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL31859 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL31838 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL28603 | — | EC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL28980 | — | EC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL282160 | — | EC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL28419 | — | EC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL28300 | — | EC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL28683 | — | EC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL628 | PENTOXIFYLLINE | EC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL1355736 | THEOPHYLLINE | EC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL283020 | — | EC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL28879 | — | EC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL28298 | — | EC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL27970 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL29209 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL29052 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL27915 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL28295 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL286741 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL28684 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL281972 | — | EC50 | > | 100000.0 | nM | - |