Assay Detail
Functional
CHEMBL685496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the electrically induced muscle contractions was determined using the guinea pig ileum
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 8.02 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434075 | — | — | 1 | 9.17 |
| CHEMBL349120 | — | — | 1 | 9.03 |
| CHEMBL346514 | — | — | 1 | 8.96 |
| CHEMBL157095 | — | — | 1 | 8.91 |
| CHEMBL345683 | — | — | 1 | 8.91 |
| CHEMBL155892 | — | — | 2 | 8.47 |
| CHEMBL346987 | — | — | 1 | 8.40 |
| CHEMBL157294 | — | — | 1 | 8.39 |
| CHEMBL345431 | — | — | 1 | 8.39 |
| CHEMBL348415 | — | — | 1 | 8.36 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.35 |
| CHEMBL155797 | — | — | 1 | 8.31 |
| CHEMBL156230 | — | — | 1 | 8.25 |
| CHEMBL422877 | — | — | 1 | 8.22 |
| CHEMBL156440 | — | — | 1 | 8.18 |
| CHEMBL157660 | — | — | 1 | 7.94 |
| CHEMBL158205 | — | — | 1 | 7.75 |
| CHEMBL155748 | — | — | 1 | 7.39 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.29 |
| CHEMBL156584 | — | — | 1 | 7.22 |
| CHEMBL25230 | — | — | 1 | 6.82 |
| CHEMBL348585 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434075 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL349120 | — | EC50 | = | 0.94 | nM | 9.03 |
| CHEMBL346514 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL345683 | — | EC50 | = | 1.22 | nM | 8.91 |
| CHEMBL157095 | — | EC50 | = | 1.23 | nM | 8.91 |
| CHEMBL155892 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL346987 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL345431 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL157294 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL348415 | — | EC50 | = | 4.35 | nM | 8.36 |
| CHEMBL596 | FENTANYL | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL155797 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL156230 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL422877 | — | EC50 | = | 6.07 | nM | 8.22 |
| CHEMBL156440 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL157660 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL158205 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL155748 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL70 | MORPHINE | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL156584 | — | EC50 | = | 59.5 | nM | 7.22 |
| CHEMBL25230 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL348585 | — | EC50 | = | 1053.0 | nM | 5.98 |
| CHEMBL155892 | — | EC50 | = | 1800.0 | nM | 5.75 |