Assay Detail
Binding
CHEMBL685533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Geranylgeranyl transferase type I
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.21 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71714 | — | — | 1 | 4.46 |
| CHEMBL301667 | — | — | 1 | 4.36 |
| CHEMBL417600 | — | — | 1 | 4.00 |
| CHEMBL71370 | — | — | 1 | 4.00 |
| CHEMBL55527 | — | — | 1 | - |
| CHEMBL292164 | — | — | 1 | - |
| CHEMBL53732 | — | — | 1 | - |
| CHEMBL72126 | — | — | 1 | - |
| CHEMBL306793 | — | — | 1 | - |
| CHEMBL69076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71714 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL301667 | — | IC50 | = | 43600.0 | nM | 4.36 |
| CHEMBL417600 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL71370 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL55527 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL292164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72126 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL306793 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL69076 | — | IC50 | > | 100000.0 | nM | - |