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Assay Detail

CHEMBL685588

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Functional
Ability to prevent constrictions induced by SRS-A (slow reacting substance of anaphylaxis) in guinea pig ileum
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Antagonists of slow-reacting substance of anaphylaxis. 1. Pyrido[2,1-b]quinazolinecarboxylic acid derivatives.
Tilley JW, Levitan P, Welton AF, Crowley HJ.
J Med Chem (1983) 26 : 1638 -1642
PubMed 6313920 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.69 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267976 FPL-55712 SODIUM SALT 1 7.46
CHEMBL544953 1 6.00
CHEMBL542834 1 6.00
CHEMBL543066 1 6.00
CHEMBL545658 1 6.00
CHEMBL542356 1 6.00
CHEMBL557024 1 6.00
CHEMBL543302 1 6.00
CHEMBL557614 1 5.70
CHEMBL537985 1 5.60
CHEMBL542603 1 5.40
CHEMBL552665 1 5.30
CHEMBL545657 1 5.22
CHEMBL545187 1 5.00
CHEMBL555988 1 5.00
CHEMBL1202593 1 5.00
CHEMBL538999 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267976 FPL-55712 SODIUM SALT IC50 = 35.0 nM 7.46
CHEMBL544953 IC50 = 1000.0 nM 6.00
CHEMBL542834 IC50 = 1000.0 nM 6.00
CHEMBL543066 IC50 = 1000.0 nM 6.00
CHEMBL545658 IC50 = 1000.0 nM 6.00
CHEMBL542356 IC50 = 1000.0 nM 6.00
CHEMBL557024 IC50 = 1000.0 nM 6.00
CHEMBL543302 IC50 = 1000.0 nM 6.00
CHEMBL557614 IC50 = 2000.0 nM 5.70
CHEMBL537985 IC50 = 2500.0 nM 5.60
CHEMBL542603 IC50 = 4000.0 nM 5.40
CHEMBL552665 IC50 = 5000.0 nM 5.30
CHEMBL545657 IC50 = 6000.0 nM 5.22
CHEMBL545187 IC50 = 10000.0 nM 5.00
CHEMBL555988 IC50 = 10000.0 nM 5.00
CHEMBL1202593 IC50 = 10000.0 nM 5.00
CHEMBL538999 IC50 = 10000.0 nM 5.00