Assay Detail
Binding
CHEMBL686016
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Inhibitory potency of Fatty-acid amide hydrolase with Mouse brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.34 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113262 | METHOXYARACHIDONOYL FLUOROPHOSPHONATE | — | 1 | 10.00 |
| CHEMBL112486 | — | — | 1 | 9.96 |
| CHEMBL113263 | METHYL DODECYLPHOSPHONOFLUORIDOATE | — | 1 | 8.70 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113262 | METHOXYARACHIDONOYL FLUOROPHOSPHONATE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL112486 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL113263 | METHYL DODECYLPHOSPHONOFLUORIDOATE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | IC50 | = | 2.0 | nM | 8.70 |