Assay Detail
Functional
CHEMBL686211
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Antagonism to 2-methyl-5-HT induced contractions in guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.42 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90769 | — | — | 1 | 10.20 |
| CHEMBL2130744 | — | — | 1 | 8.40 |
| CHEMBL92529 | — | — | 1 | 7.20 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 6.90 |
| CHEMBL330471 | — | — | 1 | 6.00 |
| CHEMBL92871 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90769 | — | Kd | = | 0.0631 | nM | 10.20 |
| CHEMBL2130744 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL92529 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL46 | ONDANSETRON | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL330471 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL92871 | — | Kd | = | 1584.89 | nM | 5.80 |