Assay Detail

CHEMBL686217

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Functional

Antagonistic activity of leukotriene D4-induced contractions of non-tonal guinea-pig trachea

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Cavia porcellus (CHEMBL369) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Trachea
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

Labelle M, Belley M, Gareau Y, Gauthier J, Guay D, Gordon R, Grossman S, Jones T, Leblanc Y, McAuliffe M, McFarlane C, Masson P, Metters K, Ouimet N, Patrick D, Piechuta H, Rochette C, Sawyer N, Xiang Y, Pickett C, Ford-Hutchinson A, Zamboni R, Young R
Bioorg Med Chem Lett (1995) 5 : 283 -288
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	9.30	9.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL787	MONTELUKAST	4.0	1	9.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL787	MONTELUKAST	Kd	=	0.5012	nM	9.30