Assay Detail
Functional
CHEMBL686244
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Antimuscarinic activity in guinea pig ileum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: 4,4-disubstituted hexahydro-3H-pyrido[1,2-c]pyrimidin-3-ones and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.05 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517 | DISOPYRAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL286259 | ACTISOMIDE | 2.0 | 1 | 4.88 |
| CHEMBL281089 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517 | DISOPYRAMIDE | Kd | = | 891.25 | nM | 6.05 |
| CHEMBL286259 | ACTISOMIDE | Kd | = | 13182.57 | nM | 4.88 |
| CHEMBL281089 | — | Kd | = | 60255.96 | nM | 4.22 |