Assay Detail
Functional
CHEMBL686245
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Antimuscarinic activity was assayed for its ability to block the acetyl-choline induced contraction of the guinea pig ileum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.99 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287868 | AZAPROPHEN | — | 1 | 10.40 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.70 |
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | — | 1 | 8.70 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 8.50 |
| CHEMBL70352 | BENACTYZINE | 2.0 | 1 | 8.20 |
| CHEMBL353846 | ADIPHENINE | 2.0 | 1 | 7.10 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287868 | AZAPROPHEN | Kd | = | 0.03981 | nM | 10.40 |
| CHEMBL517712 | ATROPINE | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL26505 | APROFENE | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL70352 | BENACTYZINE | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL353846 | ADIPHENINE | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL9967 | PIRENZEPINE | Kd | = | 50118.72 | nM | 4.30 |