Assay Detail
Binding
CHEMBL686309
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Inhibitory concentration against glycogen synthase kinase-3 alpha
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.46 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260417 | — | — | 1 | 9.10 |
| CHEMBL407981 | — | — | 1 | 8.40 |
| CHEMBL288143 | — | — | 1 | 8.40 |
| CHEMBL260416 | — | — | 1 | 8.30 |
| CHEMBL407980 | — | — | 1 | 8.15 |
| CHEMBL408564 | — | — | 1 | 8.15 |
| CHEMBL259838 | — | — | 1 | 8.15 |
| CHEMBL405145 | — | — | 1 | 8.10 |
| CHEMBL408019 | — | — | 1 | 7.92 |
| CHEMBL317657 | — | — | 1 | 7.85 |
| CHEMBL260163 | — | — | 1 | 7.82 |
| CHEMBL406644 | — | — | 1 | 7.80 |
| CHEMBL101747 | — | — | 1 | 7.75 |
| CHEMBL427909 | — | — | 1 | 7.62 |
| CHEMBL260243 | — | — | 1 | 7.46 |
| CHEMBL260231 | — | — | 1 | 7.41 |
| CHEMBL261659 | — | — | 1 | 7.38 |
| CHEMBL421207 | — | — | 1 | 7.30 |
| CHEMBL259270 | — | — | 1 | 7.12 |
| CHEMBL261690 | — | — | 1 | 7.00 |
| CHEMBL101804 | — | — | 1 | 6.85 |
| CHEMBL318522 | — | — | 1 | 6.67 |
| CHEMBL260135 | — | — | 1 | 6.60 |
| CHEMBL260929 | — | — | 1 | 6.50 |
| CHEMBL260928 | — | — | 1 | 6.48 |
| CHEMBL407113 | — | — | 1 | 6.32 |
| CHEMBL405021 | — | — | 1 | 6.30 |
| CHEMBL261660 | — | — | 1 | 6.08 |
| CHEMBL102936 | — | — | 1 | - |
| CHEMBL280221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260417 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL407981 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL288143 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL260416 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL407980 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL408564 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL259838 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL405145 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL408019 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL317657 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL260163 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL406644 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL101747 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL427909 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL260243 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL260231 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL261659 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL421207 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL259270 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL261690 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL101804 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL318522 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL260135 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL260929 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL260928 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL407113 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL405021 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL261660 | — | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL261440 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL103099 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL103098 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL103112 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL105213 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL103080 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL106060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL419903 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL280221 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL102936 | — | IC50 | > | 1000.0 | nM | - |