Assay Detail
Binding
CHEMBL686439
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In vitro binding assay of Shc-derived phosphopeptide to Growth factor receptor bound protein 2 SH2 in B104-1-1 cells was determined
16
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | B104-1-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Growth factor receptor-bound protein 2 (CHEMBL4830) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Natural and synthetic analogues of actinomycin D as Grb2-SH2 domain blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.75 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369548 | — | — | 2 | 6.30 |
| CHEMBL2369547 | — | — | 2 | 6.10 |
| CHEMBL2369549 | — | — | 2 | 6.10 |
| CHEMBL2372234 | — | — | 1 | 6.05 |
| CHEMBL2372235 | — | — | 1 | 6.00 |
| CHEMBL2372236 | — | — | 1 | 5.92 |
| CHEMBL2372231 | — | — | 1 | 5.82 |
| CHEMBL2372240 | — | — | 1 | 5.75 |
| CHEMBL2372239 | — | — | 1 | 5.70 |
| CHEMBL2372241 | — | — | 1 | 5.70 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 5.30 |
| CHEMBL2369551 | — | — | 1 | 5.23 |
| CHEMBL2369550 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369548 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2369547 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2369549 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2372234 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2372235 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2372236 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2372231 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2372240 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2372239 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2372241 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2369548 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2369551 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2369550 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2369549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2369547 | — | IC50 | > | 10000.0 | nM | - |