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Assay Detail

CHEMBL686618

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Potency in displacing [3H]Boc(Nle28,Nle31)-CCk27-33 from guinea pig pancreatic acini.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 1 — Organism
Curated By Intermediate

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Synthesis and biological activity of CCK26-33-related analogues modified in position 31.
Marseigne I, Dor A, Bégué D, Reibaud M, Zundel JL, Blanchard JC, Pélaprat D, Roques BP.
J Med Chem (1988) 31 : 966 -970
PubMed 2452253 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 7 7.24 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1121 SINCALIDE 4.0 1 8.60
CHEMBL384035 1 8.54
CHEMBL409963 1 7.24
CHEMBL264597 1 6.66
CHEMBL410230 1 6.41
CHEMBL409220 1 5.96
CHEMBL409961 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1121 SINCALIDE Ki = 2.5 nM 8.60
CHEMBL384035 Ki = 2.9 nM 8.54
CHEMBL409963 Ki = 57.0 nM 7.24
CHEMBL264597 Ki = 220.0 nM 6.66
CHEMBL410230 Ki = 390.0 nM 6.41
CHEMBL409220 Ki = 1100.0 nM 5.96
CHEMBL409961 Ki > 10000.0 nM -