Assay Detail
Functional
CHEMBL686652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its effect on EFS stimulated neuronal cholinergic contractions of guinea pig tracheal rings after 10 minutes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.34 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32102 | HOMOHYPOTAURINE | — | 1 | 5.77 |
| CHEMBL553273 | — | — | 1 | 5.58 |
| CHEMBL545424 | — | — | 1 | 5.38 |
| CHEMBL701 | BACLOFEN | 4.0 | 1 | 5.19 |
| CHEMBL542848 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32102 | HOMOHYPOTAURINE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL553273 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL545424 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL701 | BACLOFEN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL542848 | — | IC50 | = | 16000.0 | nM | 4.80 |