Assay Detail
Functional
CHEMBL686672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit nonspecific binding of [125I]BH-SP to guinea pig ileal membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of side-chain conformationally restricted phenylalanines and their use for structure-activity studies on tachykinin NK-1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.13 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372521 | — | — | 1 | 8.10 |
| CHEMBL415600 | — | — | 1 | 7.72 |
| CHEMBL265155 | — | — | 1 | 7.70 |
| CHEMBL2114442 | — | — | 1 | 7.64 |
| CHEMBL2372519 | — | — | 1 | 7.31 |
| CHEMBL411230 | — | — | 1 | 7.13 |
| CHEMBL264353 | — | — | 1 | 6.96 |
| CHEMBL410808 | — | — | 1 | 6.58 |
| CHEMBL2372517 | — | — | 1 | 6.58 |
| CHEMBL2372525 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372521 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL415600 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL265155 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2114442 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2372519 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL411230 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL264353 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL410808 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2372517 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2372525 | — | IC50 | = | 2500.0 | nM | 5.60 |