Assay Detail
Binding
CHEMBL686875
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In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.78 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124095 | — | — | 1 | 9.52 |
| CHEMBL408753 | — | — | 1 | 8.66 |
| CHEMBL125135 | — | — | 1 | 7.87 |
| CHEMBL124259 | — | — | 1 | 7.22 |
| CHEMBL123958 | — | — | 1 | 7.05 |
| CHEMBL338166 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124095 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL408753 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL125135 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL124259 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL123958 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL338166 | — | IC50 | = | 440.0 | nM | 6.36 |