Assay Detail
Functional
CHEMBL686878
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Inhibition of leukotriene-induced contractions of peripheral guinea pig lung strip
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.05 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | — | 1 | 9.40 |
| CHEMBL93991 | — | — | 1 | 7.85 |
| CHEMBL317945 | — | — | 1 | 7.80 |
| CHEMBL328815 | — | — | 1 | 7.70 |
| CHEMBL96592 | — | — | 1 | 7.70 |
| CHEMBL421750 | — | — | 1 | 7.66 |
| CHEMBL97400 | — | — | 1 | 7.62 |
| CHEMBL97656 | — | — | 1 | 7.57 |
| CHEMBL97713 | — | — | 1 | 7.52 |
| CHEMBL97356 | — | — | 1 | 7.50 |
| CHEMBL420082 | — | — | 1 | 7.43 |
| CHEMBL97541 | — | — | 1 | 7.35 |
| CHEMBL98232 | — | — | 1 | 7.35 |
| CHEMBL94465 | — | — | 1 | 7.25 |
| CHEMBL94443 | — | — | 1 | 7.22 |
| CHEMBL97401 | — | — | 1 | 7.19 |
| CHEMBL420819 | — | — | 1 | 7.16 |
| CHEMBL97359 | — | — | 1 | 7.12 |
| CHEMBL418551 | — | — | 1 | 7.10 |
| CHEMBL94456 | — | — | 1 | 7.05 |
| CHEMBL95049 | — | — | 1 | 7.00 |
| CHEMBL264799 | — | — | 1 | 6.98 |
| CHEMBL329753 | — | — | 1 | 6.82 |
| CHEMBL93877 | — | — | 1 | 6.77 |
| CHEMBL18471 | — | — | 1 | 6.62 |
| CHEMBL98517 | — | — | 1 | 6.60 |
| CHEMBL97287 | — | — | 1 | 6.60 |
| CHEMBL94893 | — | — | 1 | 6.43 |
| CHEMBL97743 | — | — | 1 | 6.35 |
| CHEMBL97693 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL93991 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL317945 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL328815 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL96592 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL421750 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL97400 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL97656 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL97713 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL97356 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL420082 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL97541 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL98232 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL94465 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL94443 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL97401 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL420819 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL97359 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL418551 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL94456 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL95049 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL264799 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL329753 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL93877 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL18471 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL98517 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL97287 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL94893 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL97743 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL97693 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL94945 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL94949 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL277292 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL267475 | FPL-55712 | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL318021 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL162358 | TOMELUKAST | IC50 | = | 1500.0 | nM | 5.82 |