Assay Detail
Functional
CHEMBL687228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against HCMV protease.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human herpesvirus 5 strain AD169 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Capsid scaffolding protein (CHEMBL3771) ↗| Type | SINGLE PROTEIN |
| Organism | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Publication
Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.12 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56849 | — | — | 1 | 8.57 |
| CHEMBL293262 | — | — | 1 | 8.55 |
| CHEMBL56210 | — | — | 1 | 8.51 |
| CHEMBL299043 | — | — | 1 | 8.49 |
| CHEMBL442168 | — | — | 1 | 8.49 |
| CHEMBL433457 | — | — | 1 | 8.47 |
| CHEMBL299278 | — | — | 1 | 8.43 |
| CHEMBL56633 | — | — | 1 | 8.37 |
| CHEMBL54930 | — | — | 1 | 8.33 |
| CHEMBL57560 | — | — | 1 | 8.32 |
| CHEMBL55390 | — | — | 1 | 8.29 |
| CHEMBL57565 | — | — | 1 | 8.21 |
| CHEMBL293998 | — | — | 1 | 8.20 |
| CHEMBL299063 | — | — | 1 | 8.19 |
| CHEMBL59436 | — | — | 1 | 8.18 |
| CHEMBL440672 | — | — | 1 | 8.17 |
| CHEMBL56361 | — | — | 1 | 8.16 |
| CHEMBL56307 | — | — | 1 | 8.16 |
| CHEMBL57465 | — | — | 1 | 8.13 |
| CHEMBL56153 | — | — | 1 | 8.12 |
| CHEMBL293782 | — | — | 1 | 8.08 |
| CHEMBL440297 | — | — | 1 | 8.02 |
| CHEMBL56642 | — | — | 1 | 7.98 |
| CHEMBL52599 | — | — | 1 | 7.82 |
| CHEMBL57169 | — | — | 1 | 7.82 |
| CHEMBL57617 | — | — | 1 | 7.82 |
| CHEMBL56516 | — | — | 1 | 7.82 |
| CHEMBL293304 | — | — | 1 | 7.76 |
| CHEMBL56741 | — | — | 1 | 7.67 |
| CHEMBL56701 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56849 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL293262 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL56210 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL299043 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL442168 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL433457 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL299278 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL56633 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL54930 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL57560 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL55390 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL57565 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL293998 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL299063 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL59436 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL440672 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL56361 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL56307 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL57465 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL56153 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL293782 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL440297 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL56642 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL52599 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL57169 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL57617 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL56516 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL293304 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL56741 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL56701 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL299924 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL56020 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL57561 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL56901 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL292678 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL55962 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL59252 | — | IC50 | > | 50.0 | nM | - |