Assay Detail
Functional
CHEMBL687309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit the electrically evoked contraction of the guinea pig ileum(GPI) of the Compound was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.61 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268874 | — | — | 1 | 8.96 |
| CHEMBL262963 | — | — | 1 | 8.77 |
| CHEMBL415795 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268874 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL262963 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL415795 | — | IC50 | = | 8.1 | nM | 8.09 |