Assay Detail
Functional
CHEMBL687336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Contraction and relaxation of guinea pig portal vein with KCl and glibenclamide respectively
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Portal vein |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Sulfonylurea receptors; K-ATP channels (CHEMBL2095152) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.38 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 7.70 |
| CHEMBL143181 | — | — | 1 | 7.36 |
| CHEMBL70996 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL143181 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL70996 | — | IC50 | = | 82.0 | nM | 7.09 |