Compound Detail
CHEMBL143181
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Basic Information
| ChEMBL ID | CHEMBL143181 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LJLXQHHFAKVTNP-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
373.4
MW (Da)
2.77
ALogP
4
HBA
2
HBD
83.5
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels CHEMBL2095152 | IC50 | 7.36 | 6.6733 | 44.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels | IC50 | = | 44.0 | nM | 7.36 | Contraction and relaxation of guinea pig portal vein with KCl and glibenclamide ... | 8917648 |
| Sulfonylurea receptors; K-ATP channels | IC50 | = | 470.0 | nM | 6.33 | IC50 evaluated by measuring contraction and relaxation of guinea pig bladder str... | 8917648 |
| Sulfonylurea receptors; K-ATP channels | IC50 | = | 470.0 | nM | 6.33 | Compound was measured in vitro for potassium channel opening (PCO) activity | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8917648 | 10.1021/jm960365n | Rattus norvegicus | 9 |
| 8917648 | 10.1021/jm960365n | Sulfonylurea receptors; K-ATP channels | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 8917648 | 10.1021/jm960365n | No relevant target | 1 |
| - | 10.1016/S0960-894X(97)00111-X | Sulfonylurea receptors; K-ATP channels | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine