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Assay Detail

CHEMBL687343

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of SRS-A-induced contractions in guinea pig ileum
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cysteinyl leukotriene receptor (CHEMBL2094254)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Substituted (aryloxy)alkanoic acids as antagonists of slow-reacting substance of anaphylaxis.
LeMahieu RA, Carson M, Han RJ, Nason WC, O'Donnell M, Brown DL, Crowley HJ, Welton AF.
J Med Chem (1987) 30 : 173 -178
PubMed 3027332 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.52 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267475 FPL-55712 1 7.46
CHEMBL49572 1 7.10
CHEMBL301537 1 7.00
CHEMBL51531 1 7.00
CHEMBL50987 1 6.70
CHEMBL49914 1 6.70
CHEMBL48968 1 6.70
CHEMBL298523 1 6.70
CHEMBL51034 1 6.70
CHEMBL300904 1 6.70
CHEMBL417904 1 6.52
CHEMBL50813 1 6.40
CHEMBL299396 1 6.30
CHEMBL430947 1 6.30
CHEMBL301561 1 6.00
CHEMBL301916 1 6.00
CHEMBL51002 1 5.70
CHEMBL432127 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267475 FPL-55712 IC50 = 35.0 nM 7.46
CHEMBL49572 IC50 = 80.0 nM 7.10
CHEMBL301537 IC50 = 100.0 nM 7.00
CHEMBL51531 IC50 = 100.0 nM 7.00
CHEMBL50987 IC50 = 200.0 nM 6.70
CHEMBL49914 IC50 = 200.0 nM 6.70
CHEMBL48968 IC50 = 200.0 nM 6.70
CHEMBL298523 IC50 = 200.0 nM 6.70
CHEMBL51034 IC50 = 200.0 nM 6.70
CHEMBL300904 IC50 = 200.0 nM 6.70
CHEMBL417904 IC50 = 300.0 nM 6.52
CHEMBL50813 IC50 = 400.0 nM 6.40
CHEMBL299396 IC50 = 500.0 nM 6.30
CHEMBL430947 IC50 = 500.0 nM 6.30
CHEMBL301561 IC50 = 1000.0 nM 6.00
CHEMBL301916 IC50 = 1000.0 nM 6.00
CHEMBL51002 IC50 = 2000.0 nM 5.70
CHEMBL432127 IC50 = 5000.0 nM 5.30