Assay Detail
Functional
CHEMBL687345
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In vitro inhibition of electrically evoked contractions of GPI (Guinea pig ileum)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.75 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338198 | — | — | 1 | 7.65 |
| CHEMBL339725 | — | — | 1 | 7.38 |
| CHEMBL126611 | — | — | 1 | 7.13 |
| CHEMBL126794 | — | — | 1 | 6.61 |
| CHEMBL339724 | — | — | 1 | 6.52 |
| CHEMBL129323 | — | — | 1 | 6.33 |
| CHEMBL338572 | — | — | 1 | 6.30 |
| CHEMBL338113 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338198 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL339725 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL126611 | — | IC50 | = | 74.5 | nM | 7.13 |
| CHEMBL126794 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL339724 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL129323 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL338572 | — | IC50 | = | 502.0 | nM | 6.30 |
| CHEMBL338113 | — | IC50 | = | 860.0 | nM | 6.07 |