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Assay Detail

CHEMBL687392

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Functional
Evaluated for inhibition of the formation and release of SRS-A in isolated guinea pig ileum
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity.
Aizawa Y, Kanai T, Hasegawa K, Yamaguchi T, Iizuka Y, Iwaoka T, Yoshioka T.
J Med Chem (1990) 33 : 1491 -1496
PubMed 2329571 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.38 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38172 1 5.82
CHEMBL285453 1 5.68
CHEMBL277815 1 5.62
CHEMBL36936 1 5.51
CHEMBL290579 1 5.42
CHEMBL285731 1 5.35
CHEMBL290417 1 5.18
CHEMBL36895 1 4.95
CHEMBL36043 1 4.92
CHEMBL35004 1 -
CHEMBL34380 1 -
CHEMBL274642 BW-755C 1 -
CHEMBL8562 1 -
CHEMBL35930 1 -
CHEMBL35990 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38172 IC50 = 1500.0 nM 5.82
CHEMBL285453 IC50 = 2100.0 nM 5.68
CHEMBL277815 IC50 = 2400.0 nM 5.62
CHEMBL36936 IC50 = 3100.0 nM 5.51
CHEMBL290579 IC50 = 3800.0 nM 5.42
CHEMBL285731 IC50 = 4500.0 nM 5.35
CHEMBL290417 IC50 = 6600.0 nM 5.18
CHEMBL36895 IC50 = 11200.0 nM 4.95
CHEMBL36043 IC50 = 11900.0 nM 4.92
CHEMBL35004 IC50 > 35600.0 nM -
CHEMBL34380 IC50 > 64800.0 nM -
CHEMBL274642 BW-755C IC50 = 136000.0 nM -
CHEMBL8562 IC50 = 147000.0 nM -
CHEMBL35930 IC50 > 37200.0 nM -
CHEMBL35990 IC50 > 33900.0 nM -