Assay Detail
Functional
CHEMBL687399
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Ex vivo inhibition of LTD4 induced contraction of guinea pig ileum.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.39 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416769 | — | — | 1 | 7.82 |
| CHEMBL34835 | — | — | 1 | 7.55 |
| CHEMBL284624 | — | — | 1 | 7.38 |
| CHEMBL32138 | — | — | 1 | 7.21 |
| CHEMBL32136 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416769 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL34835 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL284624 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL32138 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL32136 | — | IC50 | = | 100.0 | nM | 7.00 |