Assay Detail
Functional
CHEMBL687401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of guinea pig ileum longitudinal muscle strips to antagonize electrically stimulated contractions
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.66 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517 | DISOPYRAMIDE | 4.0 | 1 | 5.82 |
| CHEMBL1307 | N-MONODEISOPROPYL DISOPYRAMIDE | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517 | DISOPYRAMIDE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1307 | N-MONODEISOPROPYL DISOPYRAMIDE | IC50 | = | 3200.0 | nM | 5.50 |