Assay Detail
Functional
CHEMBL687453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Calcium channel antagonist activity against carbachol-induced contractile response in guinea pig ileal longitudinal smooth muscle
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.93 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1480 | FELODIPINE | 4.0 | 1 | 8.84 |
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 7.83 |
| CHEMBL341772 | — | — | 1 | 7.52 |
| CHEMBL343121 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1480 | FELODIPINE | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL1428 | NIMODIPINE | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL341772 | — | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL343121 | — | IC50 | = | 31.0 | nM | 7.51 |