Assay Detail
Functional
CHEMBL687578
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration producing 50% of the maximal increase in the force of contraction in isolated guinea pig left atrium
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na(+),K(+)-ATPase receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 5.91 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2068972 | — | — | 1 | 7.46 |
| CHEMBL2068887 | — | — | 1 | 7.30 |
| CHEMBL2068896 | — | — | 1 | 7.24 |
| CHEMBL2069110 | — | — | 1 | 7.16 |
| CHEMBL2068909 | — | — | 1 | 7.16 |
| CHEMBL2068904 | — | — | 1 | 6.77 |
| CHEMBL2068894 | — | — | 1 | 6.75 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.42 |
| CHEMBL2069040 | — | — | 1 | 6.42 |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 6.24 |
| CHEMBL2068901 | — | — | 1 | 6.21 |
| CHEMBL2069059 | — | — | 1 | 6.19 |
| CHEMBL2068983 | — | — | 1 | 5.96 |
| CHEMBL2068979 | — | — | 1 | 5.89 |
| CHEMBL2068897 | — | — | 1 | 5.75 |
| CHEMBL2068895 | — | — | 1 | 5.54 |
| CHEMBL2069060 | — | — | 1 | 5.41 |
| CHEMBL2068890 | — | — | 1 | 5.40 |
| CHEMBL2069048 | — | — | 1 | 5.40 |
| CHEMBL2068984 | — | — | 1 | 5.33 |
| CHEMBL2069061 | — | — | 1 | 5.10 |
| CHEMBL2068981 | — | — | 1 | 4.96 |
| CHEMBL2068978 | — | — | 1 | 4.92 |
| CHEMBL2068910 | — | — | 1 | 4.75 |
| CHEMBL2069058 | — | — | 1 | 4.70 |
| CHEMBL2068893 | — | — | 1 | 4.64 |
| CHEMBL2069044 | — | — | 1 | 4.41 |
| CHEMBL2068902 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2068972 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2068887 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2068896 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2069110 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2068909 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2068904 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2068894 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1751 | DIGOXIN | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2069040 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1453 | DIGITOXIGENIN | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2068901 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2069059 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2068983 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2068979 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2068897 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2068895 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2069060 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2068890 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2069048 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2068984 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2069061 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2068981 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2068978 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2068910 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2069058 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2068893 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2069044 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL2068902 | — | EC50 | = | - | nM | - |