Assay Detail
Functional
CHEMBL687579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inotropic activity was determined by the affects of contractile force on guinea pig left atrium.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, cardiotonic activity, and structure-activity relationships of 17 beta-guanylhydrazone derivatives of 5 beta-androstane-3 beta, 14 beta-diol acting on the Na+,K(+)-ATPase receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.43 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2068996 | — | — | 1 | 6.40 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.40 |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 6.22 |
| CHEMBL2068885 | — | — | 1 | 5.40 |
| CHEMBL2068992 | — | — | 1 | 5.30 |
| CHEMBL2069057 | — | — | 1 | 5.10 |
| CHEMBL2068935 | — | — | 1 | 5.05 |
| CHEMBL2069128 | — | — | 1 | 4.85 |
| CHEMBL2068936 | — | — | 1 | 4.82 |
| CHEMBL2068942 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2068996 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1751 | DIGOXIN | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1453 | DIGITOXIGENIN | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2068885 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2068992 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2069057 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2068935 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2069128 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2068936 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2068942 | — | EC50 | = | 17000.0 | nM | 4.77 |